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PharmDr. Ondřej Benek, Ph.D.
- Workplace: PřF - Department of Chemistry
- assistant professor
- Workplace: PřF - Academic Senate of the Faculty of Science
- Academic Staff Representative
- E-mail: ondrej.benek@uhk.cz
- Phone: 493332783
- Building: S
- Room: 73850 3. floor
Academic profiles
UHK Publications
UNIVERZITA HRADEC KRÁLOVÉ. Deriváty 2-arylbenzothiazolu, způsob jejich přípravy a jejich použití, Původci: MUSÍLEK, Kamil, O. BENEK, L. ZEMANOVÁ2024. Číslo patentu: 310144.
HALEČKOVÁ, Annamária, V. SYROVÁ, A. JOKLOVÁ, T. VERNEROVÁ, J. HURDÁLEK, R. ENDLICHER, K. ŠALAMONOVÁ, P. BŮBELOVÁ, HFF. KURNIA, M. SCHMIDT, K. MUSÍLEK, L. ZEMANOVÁ, O. BENEK. Neuroprotective Effect of 2-(Benzyloxy)arylureas Is Not Related to CypD Inhibition nor Suppression of mPTP Opening. ACS Medicinal Chemistry Letters. 2024, 15 (10), 1756-1763. ISSN 1948-5875.
BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.
HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.
SCHMIDT, Monika, M. VAŠKOVÁ, A. ROTTEROVÁ, P. FIANDOVÁ, M. MIŠKEŘÍKOVÁ, L. ZEMANOVÁ, O. BENEK, K. MUSÍLEK. Physiologically relevant fluorescent assay for identification of 17β-hydroxysteroid dehydrogenase type 10 inhibitors. Journal of Neurochemistry. 2023, 167 (2), 154-167. ISSN 0022-3042.
UNIVERZITA HRADEC KRÁLOVÉ. Monopyridiniové soli pro reaktivaci organofosfáty inhibované acetylcholinesterasy, Původci: MUSÍLEK, Kamil, D. MALIŇÁK, O. BENEK2022. Číslo patentu: 309 329.
HALEČKOVÁ, Annamária, O. BENEK, L. ZEMANOVÁ, R. DOLEŽAL, K. MUSÍLEK. Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases. Medicinal Research Reviews. 2022, 42 (5), 1822-1855. ISSN 0198-6325.
FISAR, Zdenek, K. MUSÍLEK, O. BENEK, L. HROCH, L. VINKLÁŘOVÁ, M. SCHMIDT, J. HROUDOVA, J. RABOCH. Effects of novel 17 beta-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration. Toxicology letters. 2021, 339 (15.3.2021), 12-19. ISSN 0378-4274.
DURCIK, M., Á. NYERGES, S. SKOK, D. SKLEDAR, J. TRONTELJ, N. ZIDAR, J. ILAŠ, A. ZEGA, C. CRUZ, P. TAMMELA, M. WELIN, Y. KIMBUNG, D. FOCHT, O. BENEK, T. RÉVÉSZ, G. DRASKOVITS, P. SZILI, L. DARUKA, C. PÁL, D. KIKELJ, L. MAŠIČ, T. TOMAŠIČ. New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens. European journal of medicinal chemistry. 2021, 213 (březen), "Article Number: 113200". ISSN 0223-5234.
BENEK, Ondřej, J. KORABECNY, O. SOUKUP. A Perspective on Multi-target Drugs for Alzheimer's Disease. TRENDS IN PHARMACOLOGICAL SCIENCES. 2020, 41 (7), 434-445. ISSN 0165-6147.
SCHMIDT, Monika, O. BENEK, L. VINKLÁŘOVÁ, M. HRABINOVA, L. ZEMANOVÁ, M. CHRIBEK, V. KRALOVA, L. HROCH, R. DOLEŽAL, A. LYČKA, L. PRCHAL, D. JUN, L. AITKEN, F. GUNN-MOORE, K. KUČA, K. MUSÍLEK. Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17 beta-HSD10 with Implications to Alzheimer's Disease Treatment. International journal of molecular sciences. 2020, 21 (6), "Article Number: 2059". ISSN 1661-6596.
SKOK, Ziga, M. BARANCOKOVA, O. BENEK, CD. CRUZ, P. TAMMELA, T. TOMASIC, N. ZIDAR, LP. MASIC, A. ZEGA, CEM. STEVENSON, JEA. MUNDY, DM. LAWSON, A. MAXWELL, D. KIKELJ, J. ILAS. Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors. ACS Medicinal Chemistry Letters. 2020, 11 (12), 2433-2440. ISSN 1948-5875.
VINKLÁŘOVÁ, Lucie, M. SCHMIDT, O. BENEK, K. KUČA, F. GUNN-MOORE, K. MUSÍLEK. Friend or enemy? Review of 17 beta-HSD10 and its role in human health or disease. JOURNAL OF NEUROCHEMISTRY. 2020, 155 (3), 231-249. ISSN 0022-3042.
ZEMANOVÁ, Lucie, M. VAŠKOVÁ, M. SCHMIDT, J. ROUBALOVÁ, A. HALEČKOVÁ, O. BENEK, K. MUSÍLEK. RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity: A Novel In Vitro Method Applicable in Drug Research and Discovery. Biochemistry. 2020, 59 (17), 1680-1687. ISSN 0006-2960.
HYMPÁNOVÁ, Michaela, T. KUČERA, O. BENEK, J. KORÁBEČNÝ, J. MAREK. Searching for new antimicrobial agents by targeting bacterial nad metabolism: Evaluation of frentizole derivatives selected by molecular docking. Vojenské zdravotnické listy=Military medical science letters. 2020, 89 (2), 66-73. ISSN 0372-7025.
UNIVERZITA HRADEC KRÁLOVÉ. Deriváty arylbenzothiazolylmočoviny, způsob jejich přípravy a jejich použití, Původci: MUSÍLEK, Kamil, O. BENEK, L. HROCH2019. Číslo patentu: 307 796.
MUSÍLEK, Kamil, D. MALIŇÁK, O. BENEK. Monopyridiniové soli pro reaktivaci organofosfáty inhibované acetylcholinesterasy.
AITKEN, Laura, O. BENEK, BE. MCKELVIE, RE. HUGHES, L. HROCH, M. SCHMIDT, LL. MAJOR, L. VINKLÁŘOVÁ, K. KUČA, TK. SMITH, K. MUSÍLEK, FJ. GUNN-MOORE. Novel Benzothiazole-Based Ureas as 17 beta-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment. Molecules. 2019, 24 (15), "Article Number: 2757". ISSN 1420-3049.
MUSÍLEK, Kamil, O. BENEK, D. MALIŇÁK. Vývoj nových nukleofilů pro reaktivaci cholinesteras inhibovaných organofosforovými sloučeninami - závěrečná zpráva.
BENEK, Ondřej, L. HROCH, L. AITKEN, F. GUNN-MOORE, L. VINKLÁŘOVÁ, K. KUČA, D. PEREZ, C. PEREZ, A. MARTINEZ, Z. FISAR, K. MUSÍLEK. 1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders. Journal of enzyme inhibition and medicinal chemistry. 2018, 33 (1), 665-670. ISSN 1475-6366.
Resume
Position
from 2016: Postdoc/ academic fellow
Education and Qualifications
0 - 2017: PharmDr. in Medicinal chemistry, Faculty of Pharmacy, Charles University
0 - 2016: Ph.D. in Toxicology, Faculty of Military Health Sciences, University of Defence
0 - 2011: M.Sc. in Pharmacy, Faculty of Pharmacy, Charles University
