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RNDr. Dávid Maliňák, PhD.
- Workplace: PřF - Department of Chemistry
- assistant professor
- E-mail: david.malinak@uhk.cz
- Phone: 493332798
- Building: S
- Room: 73850 3. floor
Consular Hours
Consultations are possible by previous e-mail agreement only.
Academic profiles
UHK Publications
PRCHALOVÁ, Eliška, R. ANDRÝS, J. PEJCHAL, Z. KOHOUTOVÁ, K. KNITTELOVÁ, T. HOFMANOVÁ, A. SKARKA, A. DLABKOVA, M. PSOTKA, L. PRCHAL, K. MUSÍLEK, J. ZDAROVA KARASOVA, D. MALIŇÁK. Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. Archives of toxicology. 2024, 98 (9), 2937-2952. ISSN 0340-5761.
MISIACHNA, Anna, B. SVOBODOVA, J. NETOLICKY, M. CHVOJKOVA, L. KLETECKOVA, L. PRCHAL, M. NOVAK, M. HRABINOVA, T. KUCERA, L. MUCKOVA, Z. MORAVCOVA, J. KARASOVA ZDAROVA, J. PEJCHAL, F. BLAŽEK, D. MALIŇÁK, K. HAKENOVA, B. KRAUSOVA HRCKA, M. KOLCHEVA, M. LADISLAV, J. KORABECNY, J. PAHNKE, K. VALES, M. HORAK, O. SOUKUP. Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2024, 266 (February), "Article Number: 116130". ISSN 0223-5234.
KOHOUTOVÁ, Zuzana, E. PRCHALOVÁ, K. KNITTELOVÁ, K. MUSÍLEK, D. MALIŇÁK. Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds. Bioorganic Chemistry. 2024, 150 (September), "Article Number: 107526". ISSN 0045-2068.
PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.
ROUSAR, Tomas, J. HANDL, J. CAPEK, P. NYVLTOVA, E. ROUSAROVA, M. KUBAT, L. SMID, J. VANOVA, D. MALIŇÁK, K. MUSÍLEK, P. CESLA. Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells. Archives of toxicology. 2023, 97 (11), 2943-2954. ISSN 0340-5761.
KOZLOV, Oleksandr, E. HORÁKOVÁ, S. RADEMACHEROVÁ, D. MALIŇÁK, R. ANDRÝS, E. PRCHALOVÁ, M. LÍSA. Direct Chiral Supercritical Fluid Chromatography-Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols. Analytical chemistry. 2023, 95 (11), 5109-5116. ISSN 0003-2700.
HUANG, X., L. YOU, E. NEPOVIMOVÁ, M. PSOTKA, D. MALIŇÁK, M. VALKO, L. SIVAK, J. KORABECNY, Z. HEGER, V. ADAM, Q. WU, K. KUČA. Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK). Journal of enzyme inhibition and medicinal chemistry. 2023, 38 (1), "Article number: 2237209". ISSN 1475-6366.
MIKYSKOVA, Romana, O. SAPEGA, M. PSOTKA, O. NOVOTNY, Z. HODNY, S. BALINTOVA, D. MALIŇÁK, J. SVOBODOVÁ, R. ANDRÝS, D. RYSANEK, K. MUSÍLEK, M. REINIS. STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells. Molecular Medicine Reports. 2023, 27 (4), "Article Number: 81". ISSN 1791-2997.
PRCHALOVÁ, Eliška, Z. KOHOUTOVÁ, K. KNITTELOVÁ, D. MALIŇÁK, K. MUSÍLEK. Strategies for enhanced bioavailability of oxime reactivators in the central nervous system. Archives of toxicology. 2023, 97 (11), 2839-2860. ISSN 0340-5761.
ZORBAZ, Tamara, D. MALIŇÁK, T. HOFMANOVÁ, N. MARAKOVIC, S. ZUNEC, NM. HRVAT, R. ANDRÝS, M. PSOTKA, A. ZANDONA, J. SVOBODOVÁ, L. PRCHAL, S. FINGLER, M. KATALINIC, Z. KOVARIK, K. MUSÍLEK. Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. European Journal of Medicinal Chemistry. 2022, 238 (August), "Article Number: 114377". ISSN 0223-5234.
KOHOUTOVÁ, Zuzana, D. MALIŇÁK, R. ANDRÝS, J. SVOBODOVÁ, M. PSOTKA, M. SCHMIDT, L. PRCHAL, K. MUSÍLEK. Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. Journal of enzyme inhibition and medicinal chemistry. 2022, 37 (1), 760-767. ISSN 1475-6366.
UNIVERZITA HRADEC KRÁLOVÉ. Monopyridiniové soli pro reaktivaci organofosfáty inhibované acetylcholinesterasy, Původci: MUSÍLEK, Kamil, D. MALIŇÁK, O. BENEK2022. Číslo patentu: 309 329.
VANOVA, Jana, D. MALIŇÁK, R. ANDRÝS, M. KUBAT, T. MIKYSEK, E. ROUSAROVA, K. MUSÍLEK, T. ROUSAR, P. CESLA. Optimization of gradient reversed phase high performance liquid chromatography analysis of acetaminophen oxidation metabolites using linear and non-linear retention model. Journal of Chromatography A. 2022, 1669 (April), "Article Number: 462956". ISSN 0021-9673.
KARASOVA, Jana Zdarova, J. KASSA, V. HEPNAROVA, J. PEJCHAL, L. JUNOVA, R. ANDRÝS, D. MALIŇÁK, P. BZONEK, Z. KOHOUTOVÁ, K. MUSÍLEK. Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870. Food and chemical toxicology. 2022, 167 (September), "Article Number: 113236". ISSN 0278-6915.
OLEKŠÁK, Patrik, M. PSOTKA, M. VANCUROVA, O. SAPEGA, J. BIEBLOVA, M. REINIS, D. RYSANEK, R. MIKYSKOVA, K. CHALUPOVÁ, D. MALIŇÁK, J. SVOBODOVÁ, R. ANDRÝS, H. ŘEHULKOVÁ, V. ŠKOPEK, NL. PHAM, J. BARTEK, Z. HODNY, K. MUSÍLEK. Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition. Journal of enzyme inhibition and medicinal chemistry. 2021, 36 (1), 410-424. ISSN 1475-6366.
VANOVA, Nela, A. HOJNA, J. PEJCHAL, D. HERMAN, D. MALIŇÁK, E. PRCHALOVÁ, K. MUSÍLEK, JZ. KARASOVA. Determination of K869, a Novel Oxime Reactivator of Acetylcholinesterase, in Rat Body Fluids and Tissues by Liquid-Chromatography Methods: Pharmacokinetic Study. Journal of Pharmaceutical Sciences. 2021, 110 (4), 1842-1852. ISSN 0022-3549.
GORECKI, Lukas, V. HEPNAROVA, JZ. KARASOVA, M. HRABINOVA, CH. COURAGEUX, J. DIAS, T. KUCERA, T. KOBRLOVA, L. MUCKOVA, L. PRCHAL, D. MALIŇÁK, D. JUN, K. MUSÍLEK, F. WOREK, F. NACHON, O. SOUKUP, J. KORABECNY. Development of versatile and potent monoquaternary reactivators of acetylcholinesterase. Archives of toxicology. 2021, 95 (3), 985-1001. ISSN 0340-5761.
HANDL, Jiri, D. MALIŇÁK, J. CAPEK, R. ANDRÝS, E. ROUSAROVA, M. HAUSCHKE, L. BRUCKOVA, P. CESLA, T. ROUSAR, K. MUSÍLEK. Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening. Chemical research in toxicology. 2021, 34 (3), 699-703. ISSN 0893-228X.
LEE, Hyun Myung, R. ANDRÝS, J. JONCZYK, K. KIM, AG. VISHAKANTEGOWDA, D. MALIŇÁK, A. SKARKA, M. SCHMIDT, M. VAŠKOVÁ, K. LATKA, M. BAJDA, Y. JUNG, B. MALAWSKA, K. MUSÍLEK. Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates. Journal of enzyme inhibition and medicinal chemistry. 2021, 36 (1), 1-13. ISSN 1475-6366.
SALAJKOVA, Sarka, F. HAVEL, M. SRAMEK, F. NOVOTNY, D. MALIŇÁK, R. DOLEŽAL, L. PRCHAL, M. BENKOVA, O. SOUKUP, K. MUSÍLEK, K. KUČA, J. BARTEK, J. PROSKA, M. ZARSKA, Z. HODNY. The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods. International Journal of Nanomedicine. 2021, 16 (May), 3407-3427. ISSN 1178-2013.
Resume
Position
from 2016: Assist. Professor in Department of Chemistry, Faculty of Science, University of Hradec Králové
Education and Qualifications
2010: Pavol Jozef Šafárik University in Košice, Faculty of Science; RNDr.
2008 - 2013: Pavol Jozef Šafárik University in Košice, Faculty of Science; PhD.
2006 - 2008: Pavol Jozef Šafárik University in Košice, Faculty of Science; Mgr.
2003 - 2006: Pavol Jozef Šafárik University in Košice, Faculty of Science; Bc.
Work Experience
from 2016: Assist. Professor in Department of Chemistry, Faculty of Science, University of Hradec Králové
from 2013: Scientific researcher, University Hospital in Hradec Kralove
Teaching Experience
Organic chemistry I a II
Advanced organic chemistry
Reaction mechanisms in organic chemistry
Chemistry of heterocyclic compounds
Methods of structural study of organic compounds
Stereochemistry
