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prof. PharmDr. Kamil Musílek, Ph.D.
- Workplace: PřF - Department of Chemistry
- professor
- head of the Department of Chemistry
- E-mail: kamil.musilek@uhk.cz
- Phone: 493332780
- Building: S
- Room: 73840 3. floor
Academic profiles
UHK Publications
CHAKRASALI, Prashant, D. HWANG, J. LEE, E. JUNG, HL. LEE, A. RENEESH, A. SKARKA, K. MUSÍLEK, NH. NGUYEN, JS. SHIN, Y. JUNG. 7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication. European Journal of Medicinal Chemistry. 2024, 276 (October), "Article Number: 116690". ISSN 0223-5234.
PRCHALOVÁ, Eliška, R. ANDRÝS, J. PEJCHAL, Z. KOHOUTOVÁ, K. KNITTELOVÁ, T. HOFMANOVÁ, A. SKARKA, A. DLABKOVA, M. PSOTKA, L. PRCHAL, K. MUSÍLEK, J. ZDAROVA KARASOVA, D. MALIŇÁK. Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. Archives of toxicology. 2024, 98 (9), 2937-2952. ISSN 0340-5761.
HANZLOVÁ, Michaela, B. SLAVIKOVÁ, M. MOROZOVOVÁ, K. MUSÍLEK, A. ROTTEROVÁ, L. ZEMANOVÁ, E. KUDOVÁ. C-3 Steroidal Hemiesters as Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 10. ACS Omega. 2024, 9 (10), 12116-12124. ISSN 2470-1343.
UNIVERZITA HRADEC KRÁLOVÉ. Deriváty 2-arylbenzothiazolu, způsob jejich přípravy a jejich použití, Původci: MUSÍLEK, Kamil, O. BENEK, L. ZEMANOVÁ2024. Číslo patentu: 310144.
OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, P. VASICOVA, A. URBANCOKOVA, J. NOVAK, D. MAURENCOVA, P. KASHMEL, J. HOUSEROVA, R. MIKYSKOVA, O. NOVOTNY, M. REINIS, P. JUDA, M. HONS, J. KROUPOVA, D. SEDLAK, T. SULIMENKO, P. DRABER, M. CHLUBNOVÁ, E. NEPOVIMOVÁ, K. KUČA, M. LÍSA, R. ANDRÝS, T. KOBRLOVA, O. SOUKUP, J. JANOUSEK, L. PRCHAL, J. BARTEK, K. MUSÍLEK, Z. HODNY. Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities. ACS pharmacology and translational science. 2024, 7 (9), 2755–2783. ISSN 2575-9108.
UNIVERZITA HRADEC KRÁLOVÉ. Heterocyklická sloučenina pro inhibici růstu maligních tumorů, Původci: MUSÍLEK, Kamil, P. OLEKŠÁK, V. PAVLA, R. MILAN, R. DAVID2024. Číslo patentu: 310092.
HALEČKOVÁ, Annamária, V. SYROVÁ, A. JOKLOVÁ, T. VERNEROVÁ, J. HURDÁLEK, R. ENDLICHER, K. ŠALAMONOVÁ, P. BŮBELOVÁ, HFF. KURNIA, M. SCHMIDT, K. MUSÍLEK, L. ZEMANOVÁ, O. BENEK. Neuroprotective Effect of 2-(Benzyloxy)arylureas Is Not Related to CypD Inhibition nor Suppression of mPTP Opening. ACS Medicinal Chemistry Letters. 2024, 15 (10), 1756-1763. ISSN 1948-5875.
ZARSKA, Monika, O. NOVAK, T. JAKUBCOVA, F. NOVOTNY, A. URBANCOKOVA, F. HAVEL, J. NOVAK, H. RAABOVA, K. MUSÍLEK, V. FILIMONENKO, J. BARTEK, J. PROSKA, Z. HODNY. Photothermal induction of pyroptosis in malignant glioma spheroids using (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods. Colloids and Surfaces B: Biointerfaces. 2024, 243 (November), "Article Number: 114128". ISSN 0927-7765.
KOHOUTOVÁ, Zuzana, E. PRCHALOVÁ, K. KNITTELOVÁ, K. MUSÍLEK, D. MALIŇÁK. Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds. Bioorganic Chemistry. 2024, 150 (September), "Article Number: 107526". ISSN 0045-2068.
ANDRÝS, Rudolf, CH. MONNIER, E. ANTONIJEVIĆ MILJAKOVIĆ, V. MIČKOVÁ, K. MUSÍLEK, L. ZEMANOVÁ. Towards cost-effective drug discovery: Reusable immobilized enzymes for neurological disease research. Talanta. 2024, 276 (August), "Article Number: 126263". ISSN 0039-9140.
PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.
ROUSAR, Tomas, J. HANDL, J. CAPEK, P. NYVLTOVA, E. ROUSAROVA, M. KUBAT, L. SMID, J. VANOVA, D. MALIŇÁK, K. MUSÍLEK, P. CESLA. Cysteine conjugates of acetaminophen and p-aminophenol are potent inducers of cellular impairment in human proximal tubular kidney HK-2 cells. Archives of toxicology. 2023, 97 (11), 2943-2954. ISSN 0340-5761.
BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.
HANZLOVÁ, Michaela, M. SEDLÁČEK MIŠKEŘÍKOVÁ, A. ROTTEROVÁ, K. CHALUPOVÁ, K. JURKOVÁ, M. HAMŠÍKOVÁ, R. ANDRÝS, A. HALEČKOVÁ, J. SVOBODOVÁ, M. SCHMIDT, O. BENEK, K. MUSÍLEK. Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity. ACS Medicinal Chemistry Letters. 2023, 14 (12), 1724-1732. ISSN 1948-5875.
SCHMIDT, Monika, M. VAŠKOVÁ, A. ROTTEROVÁ, P. FIANDOVÁ, M. MIŠKEŘÍKOVÁ, L. ZEMANOVÁ, O. BENEK, K. MUSÍLEK. Physiologically relevant fluorescent assay for identification of 17β-hydroxysteroid dehydrogenase type 10 inhibitors. Journal of Neurochemistry. 2023, 167 (2), 154-167. ISSN 0022-3042.
JŮZA, Radomír, K. MUSÍLEK, E. MEZEIOVA, O. SOUKUP, J. KORABECNY. Recent advances in dopamine D-2 receptor ligands in the treatment of neuropsychiatric disorders. Medicinal Research Reviews. 2023, 43 (1), 55-211. ISSN 0198-6325.
MIKYSKOVA, Romana, O. SAPEGA, M. PSOTKA, O. NOVOTNY, Z. HODNY, S. BALINTOVA, D. MALIŇÁK, J. SVOBODOVÁ, R. ANDRÝS, D. RYSANEK, K. MUSÍLEK, M. REINIS. STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells. Molecular Medicine Reports. 2023, 27 (4), "Article Number: 81". ISSN 1791-2997.
PRCHALOVÁ, Eliška, Z. KOHOUTOVÁ, K. KNITTELOVÁ, D. MALIŇÁK, K. MUSÍLEK. Strategies for enhanced bioavailability of oxime reactivators in the central nervous system. Archives of toxicology. 2023, 97 (11), 2839-2860. ISSN 0340-5761.
OLEKŠÁK, Patrik, E. NEPOVIMOVÁ, Ž. CHRIENOVÁ, K. MUSÍLEK, J. PATOČKA, K. KUČA. Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021). European Journal of Medicinal Chemistry. 2022, 238 (August), "Article number: 114498". ISSN 0223-5234.
ZORBAZ, Tamara, D. MALIŇÁK, T. HOFMANOVÁ, N. MARAKOVIC, S. ZUNEC, NM. HRVAT, R. ANDRÝS, M. PSOTKA, A. ZANDONA, J. SVOBODOVÁ, L. PRCHAL, S. FINGLER, M. KATALINIC, Z. KOVARIK, K. MUSÍLEK. Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. European Journal of Medicinal Chemistry. 2022, 238 (August), "Article Number: 114377". ISSN 0223-5234.
Resume
Position
2019 - 2022: Vice-dean for International Affairs
2011 - 2022: Head of Department of Chemistry
Education and Qualifications
2019: Full Professor in Pharmaceutical Chemistry
2012: Associate Professor in Pharmaceutical Chemistry
2008: PharmDr. in Pharmaceutical Chemistry
2004 - 2007: Ph.D. in Pharmaceutical Chemistry
1999 - 2004: MSc. in Pharmacy
Work Experience
2011 - 2022: academic position, University of Hradec Kralove, Faculty of Science
2011 - 2022: scientific position, University Hospital Hradec Kralove
2006 - 2018: academic position, University of Defence, Faculty of Military Health Sciences
Teaching Experience
Medicinal Chemistry
Organic and Bioorganic Chemistry
Toxicology
Academic Stays Abroad
2009: Centre Recherche Service Santé Armée, La Tronche/Grenoble, FR
2007: University St Andrews, UK
2003 - 2004: Ruprecht-Karls-Universität Heidelberg, DE
