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RNDr. Patrik Olekšák, PhD.
- Workplace: PřF - Faculty of Science
- vice-dean for Strategy, Development and Legislation of the Faculty of the Science
- Workplace: PřF - Department of Chemistry
- assistant professor
- E-mail: patrik.oleksak@uhk.cz
- Phone: 493332752
- Building: S
- Room: 73310 3. floor
UHK Publications
PATOČKA, Jiří, M. OVANDO-MARTINEZ, Z. NAVRATILOVA, P. OLEKŠÁK, M. OGWU, E. NEPOVIMOVÁ, K. KUČA. Argemone mexicana L. (Papaveraceae): chemistry, pharmacology, and toxicology. Phytochemistry Reviews. 2024, 23 (4), 1167-1182. ISSN 1568-7767.
OLEKŠÁK, Patrik, E. NEPOVIMOVÁ, M. VALKO, S. ALWASEL, S. ALOMAR, K. KUČA. Comprehensive analysis of prohibited substances and methods in sports: Unveiling trends, pharmacokinetics, and WADA evolution. Environmental Toxicology and Pharmacology. 2024, 108 (June), "Article number: 104447". ISSN 1382-6689.
BHARDWAJ, K., R. BHARGAV, J. PATOCKA, R. SHARMA, Z. NAVRATILOVA, P. OLEKŠÁK, K. KUČA. Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review. Mini-reviews in medicinal chemistry. 2024, 24 (15), 1395-1408. ISSN 1389-5575.
OLEKŠÁK, Patrik, D. RYSANEK, M. VANCUROVA, P. VASICOVA, A. URBANCOKOVA, J. NOVAK, D. MAURENCOVA, P. KASHMEL, J. HOUSEROVA, R. MIKYSKOVA, O. NOVOTNY, M. REINIS, P. JUDA, M. HONS, J. KROUPOVA, D. SEDLAK, T. SULIMENKO, P. DRABER, M. CHLUBNOVÁ, E. NEPOVIMOVÁ, K. KUČA, M. LÍSA, R. ANDRÝS, T. KOBRLOVA, O. SOUKUP, J. JANOUSEK, L. PRCHAL, J. BARTEK, K. MUSÍLEK, Z. HODNY. Discovery of a 6-Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities. ACS pharmacology and translational science. 2024, 7 (9), 2755–2783. ISSN 2575-9108.
PATOČKA, Jiří, W. WU, P. OLEKŠÁK, R. JELINKOVA, E. NEPOVIMOVÁ, L. ŠPIČANOVÁ, P. SPRINGEROVÁ, S. ALOMAR, M. LONG, K. KUČA. Fentanyl and its derivatives: Pain-killers or man-killers?. Heliyon. 2024, 10 (8), "Article number: e28795". ISSN 2405-8440.
UNIVERZITA HRADEC KRÁLOVÉ. Heterocyklická sloučenina pro inhibici růstu maligních tumorů, Původci: MUSÍLEK, Kamil, P. OLEKŠÁK, V. PAVLA, R. MILAN, R. DAVID2024. Číslo patentu: 310092.
WANI, A.K., R. SINGH, N. AKHTAR, A. PRAKASH, E. NEPOVIMOVÁ, P. OLEKŠÁK, Ž. CHRIENOVÁ, S. ALOMAR, C. CHOPRA, K. KUČA. Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy. Mini-reviews in medicinal chemistry. 2024, 24 (16), 1496-1520. ISSN 1389-5575.
CHRIENOVÁ, Žofia, D. RYSANEK, J. NOVAK, P. VASICOVA, P. OLEKŠÁK, R. ANDRÝS, A. SKARKA, J. DUMANOVIC, Z. MILOVANOVIC, V. JACEVIC, M. CHVOJKOVA, K. HOLUBOVA, K. VALEŠ, V. SKOUPILOVÁ, M. VALKO, K. JOMOVA, S. ALOMAR, F. BOTELHO, TC. COSTA FRANCA, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Frentizole derivatives with mTOR inhibiting and senomorphic properties. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article number: 115600". ISSN 0753-3322.
JOKANOVIĆ, Milan, P. OLEKŠÁK, K. KUČA. Multiple neurological effects associated with exposure to organophosphorus pesticides in man. Toxicology. 2023, 484 (January), "Article number: 153407". ISSN 0300-483X.
JOMOVA, K., M. CVIK, P. LAURO, M. VALKO, E. CIZMAR, S. ALOMAR, S. ALWASEL, P. OLEKŠÁK, Ž. CHRIENOVÁ, E. NEPOVIMOVÁ, K. KUČA, C. RHODES. The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions. Journal of inorganic biochemistry. 2023, 245 (August), "Article number: 112244". ISSN 0162-0134.
OLEKŠÁK, Patrik, E. NEPOVIMOVÁ, Ž. CHRIENOVÁ, K. MUSÍLEK, J. PATOČKA, K. KUČA. Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015–2021). European Journal of Medicinal Chemistry. 2022, 238 (August), "Article number: 114498". ISSN 0223-5234.
CHRIENOVÁ, Žofia, D. RYSANEK, P. OLEKŠÁK, D. STARY, M. BAJDA, M. REINIS, R. MIKYSKOVA, O. NOVOTNY, R. ANDRÝS, A. SKARKA, P. VASICOVA, J. NOVAK, M. VALIS, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics. Frontiers in aging neuroscience. 2022, 14 (December), "Article Number: 1048260". ISSN 1663-4365.
CHRIENOVÁ, Ž.RYŠÁNEK, D.SKOUPILOVÁ, V.OLEKŠÁK, P.ANDRÝS, R.SKARKA, A.BOTELHO, F.COSTA FRANCA, T.C.VANČUROVÁ, M.KUČA, K.HODNÝ, Z.NEPOVIMOVÁ, E.: Mitochondrial modulators with mTOR inhibiting properties in anti-aging therapy. 2022.
YANG, L., J. WANG, Y. YANG, S. LI, T. WANG, P. OLEKŠÁK, Ž. CHRIENOVÁ, Q. WU, E. NEPOVIMOVÁ, X. ZHANG, K. KUČA. Phytoremediation of heavy metal pollution: Hotspots and future prospects. Ecotoxicology and Environmental Safety. 2022, 234 (April), "Article number: 113403". ISSN 0147-6513.
CHRIENOVÁ, Žofia, E. NEPOVIMOVÁ, R. ANDRÝS, R. DOLEZAL, J. JANOCKOVA, L. MUCKOVA, L. FABOVA, O. SOUKUP, P. OLEKŠÁK, M. VALIS, J. KORABECNY, J. MARCO-CONTELLES, K. KUČA. Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities. Journal of enzyme inhibition and medicinal chemistry. 2022, 37 (1), 2605-2620. ISSN 1475-6366.
ANAND, U., A. CHANDEL, P. OLEKŠÁK, A. MISHRA, O. KREJCAR, I. RAVAL, A. DEY, K. KUČA. Recent advances in the potential applications of luminescence-based, SPR-based, and carbon-based biosensors. Applied Microbiology and Biotechnology. 2022, 106 (8), 2827-2853. ISSN 0175-7598.
TUDU, Champa Keeya, T. DUTTA, M. GHORAI, P. BISWAS, D. SAMANTA, P. OLEKŠÁK, NK. JHA, M. KUMAR, R. RADHA, J. PROĆKÓW, JM. PÉREZ DE LA LASTRA, A. DEY. Traditional uses, phytochemistry, pharmacology and toxicology of garlic (Allium sativum), a storehouse of diverse phytochemicals: A review of research from the last decade focusing on health and nutritional implications. Frontiers in Nutrition. 2022, 9 (October), "Article Number: 949554". ISSN 2296-861X.
ALGHUTHAYMI, Mousa A., AA. HASSAN, A. KALIA, RMHS. EL AHL, AAM. EL HAMAKY, P. OLEKŠÁK, K. KUČA, KA. ABD-ELSALAM. Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects. JOURNAL OF FUNGI. 2021, 7 (7), "Article Number: 494". ISSN 2309-608X.
KUMAR, Harsh, K. BHARDWAJ, N. CRUZ-MARTINS, E. NEPOVIMOVÁ, P. OLEKŠÁK, DS. DHANJAL, S. BHARDWAJ, R. SINGH, CH. CHOPRA, R. VERMA, PP. CHAUHAN, D. KUMAR, K. KUCA. Applications of Fruit Polyphenols and Their Functionalized Nanoparticles Against Foodborne Bacteria: A Mini Review. MOLECULES. 2021, 26 (11), "Article Number: 3447". ISSN 1420-3049.
OLEKŠÁK, Patrik, M. PSOTKA, M. VANCUROVA, O. SAPEGA, J. BIEBLOVA, M. REINIS, D. RYSANEK, R. MIKYSKOVA, K. CHALUPOVÁ, D. MALIŇÁK, J. SVOBODOVÁ, R. ANDRÝS, H. ŘEHULKOVÁ, V. ŠKOPEK, NL. PHAM, J. BARTEK, Z. HODNY, K. MUSÍLEK. Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition. Journal of enzyme inhibition and medicinal chemistry. 2021, 36 (1), 410-424. ISSN 1475-6366.
Resume
Position
from 2018: Academic scientist
Education and Qualifications
from 2013: PhD degree at Pavol Jozef Šafárik University in Košice
2011 - 2013: Master degree at Pavol Jozef Šafárik University in Košice (organic chemistry)
2008 - 2011: Bachelor degree at Pavol Jozef Šafárik University in Košice (chemistry)
Work Experience
2017 - 2018: Academic scientist at Pavol Jozef Šafárik University in Košice
Teaching Experience
Laboratory techniques
Laboratory practices in organic chemistry
Laboratory practices in organic chemistry and biochemistry
Research Activities
from 2018: Synthesis of STAT3 inhibitors for cancer therapy
Academic Stays Abroad
2015: Syngenta research center in Stein, Switzerland
