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PharmDr. Adam Skarka, Ph.D.

PharmDr. Adam Skarka, Ph.D.
Workplace: PřF - Department of Chemistry
assistant professor
Workplace: PřF - Academic Senate of the Faculty of Science
Academic Staff Representative
E-mail:
Phone: 493332793
Building: S
Room: 73330 3. floor

Consular Hours

Consultations are possible by previous e-mail agreement only.

Academic profiles

UHK Publications

CHAKRASALI, Prashant, D. HWANG, J. LEE, E. JUNG, HL. LEE, A. RENEESH, A. SKARKA, K. MUSÍLEK, NH. NGUYEN, JS. SHIN, Y. JUNG. 7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication. European Journal of Medicinal Chemistry. 2024, 276 (October), "Article Number: 116690". ISSN 0223-5234.

PRCHALOVÁ, Eliška, R. ANDRÝS, J. PEJCHAL, Z. KOHOUTOVÁ, K. KNITTELOVÁ, T. HOFMANOVÁ, A. SKARKA, A. DLABKOVA, M. PSOTKA, L. PRCHAL, K. MUSÍLEK, J. ZDAROVA KARASOVA, D. MALIŇÁK. Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. Archives of toxicology. 2024, 98 (9), 2937-2952. ISSN 0340-5761.

PRCHALOVÁ, Eliška, M. SUKUPOVA, D. MALIŇÁK, R. ANDRÝS, L. SIVAK, V. PEKARIK, A. SKARKA, J. SVOBODOVÁ, L. PRCHAL, L. FRESSER, Z. HEGER, K. MUSÍLEK. BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article Number:115490". ISSN 0753-3322.

BENEK, Ondřej, M. VAŠKOVÁ, M. SEDLÁČEK MIŠKEŘÍKOVÁ, M. SCHMIDT, R. ANDRÝS, A. ROTTEROVÁ, A. SKARKA, J. HATLAPATKOVA, JZ. KARASOVA, M. MEDVECKÝ, L. HROCH, L. VINKLÁŘOVÁ, Z. FISAR, J. HROUDOVA, J. HANDL, J. CAPEK, T. ROUSAR, T. KOBRLOVA, R. DOLEZAL, O. SOUKUP, L. AITKEN, F. GUNN-MOORE, K. MUSÍLEK. Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation. European Journal of Medicinal Chemistry. 2023, 258 (říjen), "Article Number: 115593". ISSN 0223-5234.

CHRIENOVÁ, Žofia, D. RYSANEK, J. NOVAK, P. VASICOVA, P. OLEKŠÁK, R. ANDRÝS, A. SKARKA, J. DUMANOVIC, Z. MILOVANOVIC, V. JACEVIC, M. CHVOJKOVA, K. HOLUBOVA, K. VALEŠ, V. SKOUPILOVÁ, M. VALKO, K. JOMOVA, S. ALOMAR, F. BOTELHO, TC. COSTA FRANCA, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Frentizole derivatives with mTOR inhibiting and senomorphic properties. Biomedicine and Pharmacotherapy. 2023, 167 (November), "Article number: 115600". ISSN 0753-3322.

UNIVERZITA HRADEC KRÁLOVE. ProxyQB – rehabilitační kostka. Původci: GÁL, Vladimír, J. JANECZKO, L. KOVAŘÍK, O. KUBÍČEK, P. KUČA, T. MARIÁNEK, M. ORSZULÍK, V. PRŮŠA, D. PUKALÍK, M. SEIDLEROVÁ, R. SOBOTÍKOVÁ, L. STUCHLÍK, M. ŠČUPÁK, J. ŠEVČÍK, Z. ŠIMÍKOVÁ, J. VANTUCH, R. VAŠEK, P. COUFAL, A. CHOLEVOVÁ, M. KALOVÁ, K. KUČA, L. KYTNAROVÁ, P. MAREŠOVÁ, P. NILIUS, L. PETER, L. REŽNÝ, M. SCHMIDT, M. SCHMIDT, J. SKALSKÝ, A. SKARKA, P. STRAKA, J. VONDRÁK. 2023. Identifikační číslo: EG21_374/0026873.

VAGIANNIS, Dimitrios, Y. ZHANG, Y. BUDAGAGA, E. NOVOTNA, A. SKARKA, S. KAMMERER, J. KUEPPER, J. HOFMAN. Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter. Toxicology and Applied Pharmacology. 2022, 434 (JAN 1 2022), "Article Number: 115823". ISSN 0041-008X.

CHRIENOVÁ, Žofia, D. RYSANEK, P. OLEKŠÁK, D. STARY, M. BAJDA, M. REINIS, R. MIKYSKOVA, O. NOVOTNY, R. ANDRÝS, A. SKARKA, P. VASICOVA, J. NOVAK, M. VALIS, K. KUČA, Z. HODNY, E. NEPOVIMOVÁ. Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics. Frontiers in aging neuroscience. 2022, 14 (December), "Article Number: 1048260". ISSN 1663-4365.

CHRIENOVÁ, Ž.RYŠÁNEK, D.SKOUPILOVÁ, V.OLEKŠÁK, P.ANDRÝS, R.SKARKA, A.BOTELHO, F.COSTA FRANCA, T.C.VANČUROVÁ, M.KUČA, K.HODNÝ, Z.NEPOVIMOVÁ, E.: Mitochondrial modulators with mTOR inhibiting properties in anti-aging therapy. 2022.

KOMÁRKOVÁ, Martina, Z. KOVALÍKOVÁ, J. ŠIMEK, A. SKARKA, J. TŮMA. Physiological and biochemical responses of Brassica napus L. cultivars exposed to Cd stress. Plant, soil and environment. 2022, 68 (9), 431-440. ISSN 1214-1178.

SKARKOVA, Veronika, B. VITOVCOVA, P. MATOUSKOVA, M. MANETHOVA, P. KAZIMIROVA, A. SKARKA, V. BRYNYCHOVA, P. SOUCEK, H. VOSMIKOVA, E. RUDOLF. Role of N-Cadherin in Epithelial-to-Mesenchymal Transition and Chemosensitivity of Colon Carcinoma Cells. CANCERS. 2022, 14 (20), "Article Number: 5146". ISSN 2072-6694.

LEE, Hyun Myung, R. ANDRÝS, J. JONCZYK, K. KIM, AG. VISHAKANTEGOWDA, D. MALIŇÁK, A. SKARKA, M. SCHMIDT, M. VAŠKOVÁ, K. LATKA, M. BAJDA, Y. JUNG, B. MALAWSKA, K. MUSÍLEK. Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates. Journal of enzyme inhibition and medicinal chemistry. 2021, 36 (1), 1-13. ISSN 1475-6366.

SKARKOVA, Veronika, A. SKARKA, M. MANETHOVA, AA. STEFANIDI, E. RUDOLF. Silencing of E-cadherin expression leads to increased chemosensitivity to irinotecan and oxaliplatin in colorectal cancer cell lines. HUMAN & EXPERIMENTAL TOXICOLOGY. 2021, 40 (12), 2063-2073. ISSN 0960-3271.

VAGIANNIS, Dimitrios, Y. BUDAGAGA, A. MORELL, Y. ZHANG, E. NOVOTNA, A. SKARKA, S. KAMMERER, J. KUPPER, I. HANKE, T. ROZKOS, J. HOFMAN. Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021, 22 (21), "Article Number: 11936". ISSN 1422-0067.

VAGIANNIS, Dimitrios, E. NOVOTNA, A. SKARKA, S. KAMMERER, J. KUPPER, S. CHEN, L. GUO, F. STAUD, J. HOFMAN. Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme. CANCERS. 2020, 12 (4), "Article Number: 813". ISSN 2072-6694.

MUSÍLEK, Kamil, D. MALIŇÁK, E. NEPOVIMOVÁ, R. ANDRÝS, A. SKARKA, K. KUČA. Novel Cholinesterase Reactivators. In: Handbook of Toxicology of Chemical Warfare Agents, Amsterdam: Elsevier, 2020. ISBN 978-0-12-819090-6.

KUBICEK, Vladimir, L. SKALOVA, A. SKARKA, V. KRALOVA, J. HOLUBOVA, J. STEPANKOVA, Z. SUBRT, B. SZOTAKOVA. Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions. FRONTIERS IN PHARMACOLOGY. 2019, 10 (MAY), 1-9. ISSN 1663-9812.

SKARKOVA, Veronika, M. KRUPOVA, B. VITOVCOVA, A. SKARKA, P. KASPAROVA, P. KRUPA, V. KRALOVA, E. RUDOLF. The Evaluation of Glioblastoma Cell Dissociation and Its Influence on Its Behavior. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019, 20 (18), "Article Number: 4630". ISSN 1422-0067.

ZORBAZ, Tamara, D. MALIŇÁK, N. MARAKOVIC, N. HRVAT, A. ZANDONA, M. NOVOTNÝ, A. SKARKA, R. ANDRÝS, M. BENKOVA, O. SOUKUP, M. KATALINIC, K. KUČA, Z. KOVARIK, K. MUSÍLEK. Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents. Journal of medicinal chemistry. 2018, 61 (23), 10753-10766. ISSN 0022-2623.

HANUSOVA, Veronika, K. CALTOVA, H. SVOBODOVA, M. AMBROZ, A. SKARKA, N. MURINOVA, V. KRALOVA, P. TOMSIK, L. SKALOVA. The effects of beta-caryophyllene oxide and trans-nerolidol on the efficacy of doxorubicin in breast cancer cells and breast tumor-bearing mice. BIOMEDICINE & PHARMACOTHERAPY. 2017, 95 (November), 828-836. ISSN 0753-3322.

Resume

Position

from 2015: Academic staff, Department of Chemistry, Faculty fo Science, University of Hradec Kralove

2012 - 2015: Research staff, Department of Biochemistry, Faculty of Pharmacy, Charles University

Education and Qualifications

2008 - 2012: Doctoral degree, Patobiochemistry and Xenobiochemistry

2003 - 2008: Masters degree, Pharmacy

Academic Stays Abroad

2010: Institut für Toxikologie und Pharmakologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany