Localized Electronic Effects of Antibody Binding on NanoComposite Materials (LEEFAB)

New miniaturized electronic sensors of drugs will be prepared and studied in the form of coplanar impedance and conductivity devices employing a functional layer based on diamond thin films. We will investigate the impact of sensor geometry and nanostructured surfaces, including composite based on diamond and gold nanoparticles, on amplifying the signal and improving sensitivity. Based on these sensors in combination with functionalization by molecular receptors, an antibody platform will be prepared and consequently tested for the determination of selected drugs (phenytoin, digoxin, lithium, and cyclosporine) in blood. Detection properties of the novel sensor platform (detection limit, reproducibility, possibility of quantification, applicability in practice, the cost of measurement) will be compared with standard methods used in clinical practice for the specified drugs.