Surface modification of nanoparticles and cancer targets

Cancer treatment is a worldwide issue applying numerous y intensively studied strategies. Our team is trying to combat cancer via the theranostics strategy using gold nanorods. Up to the present day, we have investigated some of the surfactants valuable for the modification of gold nanorods, including their bioavailability or biocompatibility. We have developed and used plenty of variable chemical agents valuable for this purpose. Preferentially, the mechanism of action plus the safety of used nanoparticles and their modifiers is studied; this research is carried out in cooperation with our international partners.

Projects

• 18-14259S - Inhibition of JAK/STAT3 signalling pathway in cancer therapy

• 17-19968S - Localized Electronic Effects of Antibody Binding on NanoComposite Materials (LEEFAB)

• Zarska, M.; Novotny, F.; Havel, F.; Sramek, M.; Babelova, A.; Benada, O.; Novotny, M.; Saran, H.; Kuca, K.; Musilek, K.; Hvezdova, Z.; Dzijak, R.; Vancurova, M.; Krejcikova, K.; Gabajova, B.; Hanzlikova, H.; Kyjacova, L.; Bartek, J.; Proska, J.*; Hodny, Z.* A two-step mechanism of cellular uptake of cationic gold nanoparticles modified by (16-mercaptohexadecyl)trimethylammonium bromide (MTAB). Bioconjugate Chemistry. 2016, vol. 27, no. 10, p. 2558?2574. DOI: 10.1021/acs.bioconjchem.6b00491

• Zarska, M.; Sramek, M.; Novotny, F.; Havel, F.; Babelova, A; Mrazkova, B.; Benada, O.; Reinis, M.; Stepanek, I.; Musilek, K.; Bartek, J.; Ursinyova, M.; Novak, O.; Dzijak, R.; Kuca, K.*; Proska, J.*; Hodny, Z.* Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods. Biomaterials 2017, vol. 154, no. 1, p. 275-290. DOI: 10.1016/j.biomaterials.2017.10.044