Lecture: ABC Transporters: Role in Neurodegeneration & Treatment
Date of Event: 11/21/2023 12:30–13:30, Place: Building S - room S2, Hradecká 1285, 500 03 Hradec Králové
We are pleased to extend to you an invitation to an enlightening lecture titled "ABC Transporter Blood-Brain Barrier Function in Neurodegenerative and Neuroinflammatory Diseases – From Basic Research to Treatment."
When: 21 November 2023 from 12:30
Where: room S2 (ground floor of building S)
Who: Professor Jens Pahnke, M.D., Ph.D., E.F.N.
Annotation: The current understanding of neurodegenerative diseases focusses on the deposition of toxic peptide species as larger aggregates in the brain of effected individuals. However, patients with sporadic neurodegenerative diseases do not overexpress these peptides. Moreover, they are hampered in removing the physiologically produced peptides, e.g. Aβ and α-synuclein. The blood-brain barrier plays a prominent role in the active and effective removal of metabolites and in the efflux of toxic peptides from the brain into the blood stream.
Here, ABC transporters were discovered by us and others to have a fundamental role in the homeostasis of the brain’s environment. In 2011, we described a new ABC transporter (ABCC1) that increases Aβ in the brain of knock-out animals by 12-14fold. Since then, we could show that the activation of ABC transporters can be used as a diagnostic tool and a new treatment option in elderly with Alzheimer’s disease and other neurodegenerative diseases, such as Huntington’s disease.
