PhD Student – double degree (MSCA project)

The Faculty of Science University of Hradec Kralove offers a double PhD degree (co-tutelle). The successful candidate will work in the Czech Republic, Italy, and Spain, collaborating with other researchers to develop molecules that target the circadian clock and evaluate their effectiveness. This position is ideal for someone with a background in Toxicology interested in research, offering a competitive salary, comprehensive benefits, valuable experience, and academic credentials.

Offer Description:

  • University of Hradec Kralove (Faculty of Science, Department of Chemistry) is looking to appoint a Marie Curie Research Fellow within a fixed term project entitled “Hit selection strategies for identification of kinase inhibitors modulating circadian rhythm in AD”, funded by the Horizon Europe project TClock4AD.
  • The doctoral candidate (DC) will work for two years in Czech Republic (Hradec Kralove University) and for 10 months in Italy (University of Bologna) and will be involved in a 2-month secondment to a Spanish company (Ankar Pharma).
  • The goals for this DC will be to develop molecules targeting circadian clock and evaluate them in vitro using chemical/biochemical and/or cellular assays. This DC will work in close collaboration with DC1 and DC2 with the aim of optimizing drug candidates directed to particular molecular targets through quantitative mechanistic characterization and preliminary early-ADMET evaluation (including physical-chemical properties, protein binding, serum stability, prediction of BBB permeability, hepato- and neuro-toxicity). The collected data will allow to prioritize different structural classes and rank order them not only based on potency but also in relation to potential downstream absorption, metabolism, or toxicity liabilities. Complementary (bio)pharmaceutical analytical techniques will be exploited for compound profiling, including, but not limited to, surface plasmon resonance for albumin binding assays and liquid chromatography-mass spectrometry for early ADME studies and microsomal assays.
  • Study programme Toxicology
  • Benefits

 

Admission Requirements

 

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